When I was a kid in Brooklyn, a squirrel jumped out of a tree onto my friends dads back. Messed him up pretty bad.
For the next week, people were hunting squirrels and bringing the corpses in for rabies testing.
I went to Ohio State, a pedestrian campus where people routinely feed squirrels. They had so little fear that they would actually steal food out of bookbags and even people's hands if you were distracted.