Not really. It is certainly isolated, but as far as middle eastern countryside goes, it's actually one of the prettier areas in that part of the world. The problem is that the terrain is fairly rugged and forested, and there are no real "roads" into the region...just a handful of cattle and foot roads that happen to be wide enough to permit heav truck travel. Most people still travel into the area on foot or horseback. The Waziri's, interestingly, also tend to live on the ridges instead of the valleys. This gives them the strategic high ground and makes them both hard to reach and harder to drive out.
I did a quick search and found this page with some Waziristan photos:
http://www.khpalapashtu.com/sitep/specialpages/phwazir.htm. It's dry, but it's practically a paradise when compared to the dusty hellholes we fight in over in Iraq and Afghanistan.