Alas, the laws of physics do seem to change with time ~ lots of it of course, but they change nonetheless.
If the laws of physics are changing how can we possibly do physics? We're not talking about something elementary such as the possibly changing speed of light in a vacuum since a higher law can be found to explain how that works, nor with enhancements to Newtonian mechanics. We're concerned with Lorentz invariance and isotropy of space. If that is no good we will lose our Theory of Relativity and all the other high power explanations including quantum mechanics. If that is happening, we have lost the game.