No, the standard is "substantially affect", not "might possibly affect".
"If I am a doctor prescribing pot to my patients, or a dope dealer selling my homegrown weed to all my friends and and relatives, then the fed has NO BUSINESS sticking their filthy noses into it."
Normally, no. But since Congress has chosen to regulate the interstate commerce of marijuana, and since your local activities (allowed nationwide, of course) would have a substantial effect on those regulations, Congress may indeed "stick their filthy noses into it".
Pure crap. Cong. is permitted to regulate ISC, not anything that might affect ISC. The standard is "substantially affect?" is it?? No, the standard is found in the US CONS, giving cong. the power to reg. ISC, not reg. something that might sub. aff. isc. Again, EVERY "local activities allowed nationwide" could affect ISC, therefore the G. has the authority regulate EVERYTHING in your book. NO. Cong. has the authority to reg ISC, not things that may affect, ISC, growing and selling my own dope is NOT ISC, no matter how much liberals and totalitarians would like to pretend otherwise.