These results also correlate with the presence of normal histopathological features in endometrial biopsies taken during the implantation window in women from Groups B, C, and D. Indeed, in this study, the process of transformation of endometrium into decidua, as a consequence of endometrial cell differentiation independently of conception occurred normally in women receiving LNG at the time or after the occurrence of LH surge. In this regard, the existence of edematous changes along with development of prominent spiral arteries in LNG-exposed tissues strongly suggest the apparent preservation of endometrial structures thought to be associated with implantation capabilities [45,46]. A successful implantation requires an adequate synchronization between embryo and endometrium development for invasion of spiral arteries by trophoblast cells [47]. These results suggest that postovulatory contraceptive efficacy of LNG may not involve alterations in the mechanisms associated with endometrial receptivity. A similar conclusion was reached by Raymond et al. [48], where no substantial evidence for the contraceptive effect of the Yuzpe regimen at the level of endometrium could be established.
Studies in Cebus monkeys and rats have shown no interference in implantation of embryos.
In actual human usage, the pills are only effective about 70%-80% of the time, meaning that about 20% to 30% of the time, women do get pregnant.
I cannot get past the idea that lower dosages are available only by prescription because they are artififical hormonal systems, yet this bolus dosing is available OTC and will be ingested by very young females, yet science hasn't a clue what the longterm effects will be of disrupting the hormonal feedback mechanisms of young felmales! But then Murray and clinton don't actually give a damn about young females so long as they may be sacrificed in democrap empowerment schemes. Isn't she going to be just the right president for this degenerating nation? We deserve the swinehunt.
The massive Scottish study concluded that providing participants with the drug prior to unprotected sex had no effect on pregnancy or abortion rates. The British government also warned physicians that in cases of failed emergency contraception ectopic pregnancy rates were three-times the norm.
What were left with is a decision, made for purely political reasons, that angers a large segment of the President's base, has not been demonstarted to work and which may have serious medical consequences. Senseless.