I have trouble thinking of a RINO who lost in a discernably pro GOP open district in the general election, in the relatively recent past, but maybe there are some. Of course, this year might be different. But I don't think Kolbe's district is that conservative on social issues overall; in fact I tend to think it is fairly moderate.
I'm sure I can think of a few seats, though I'm a bit tired and soon to head off to bed, but the Dennis Moore seat comes to mind (although that's not an open seat, of course). Another one, albeit not a GOP seat, but one that could prove competitive, Maine-2 in '02, when we put up a pro-abort RINO against a pro-life Dem (and lo and behold, the pro-life Dem won, despite claims by certain predictable groups that he was "out of touch"). Michaud might still have won against a Conservative GOPer, but we won't know for sure. Another one was Rick Lazio's NY-2nd district in 2000 when the GOP had the brilliant notion to run a very liberal Black lady for the seat, and she was obliterated in a 4-person contest.