They are already planning for the F-35 to have a pilotless configuration. Read this.
http://www.air-attack.com/news/news_article/1980/Lockheed-Eyes-Unmanned-F-35-Amid-Push-Into-Drone-World.html
Yes, but imagine the same aircraft without any limitations due to "pilot space". If the aircraft is the same size, then it can carry another 1/2 ton of fuel, engine and firepower. If it is smaller, you still get a major jump in range and armaments.
In either case it can handle speeds and g-forces that would give it air dominance.
Still, the range of unmanned aircraft should be across the board from advanced expensive fighters to expendable, low-cost single use buzzbombs.