No doubt about it, the F22 is a fantastic plane, but how the hell is Israel going to afford a relevant number of these planes when the price tag is 330+ million dollars?
Maybe one or two, just enough to deliver some nukes to Tehran, but I seriously doubt they´re in for more.
You'd need to field a couple of squadrons at least. One squadron to train pilots & test weapons; one squadron for operational duty. F22's are not in the future for the IDF.