Unfortunately, I don't think that this country will soon vote for a Mexican First Lady.
But Jeb may have other problems because of his wife. Reading The Bushes: Portrait of a Dynasty it's obvious that Colu Bush is not to her husband what Laura Bush is to hers. One relative even said that Jeb Bush had a chip on his shoulder because of his wife and they (the family, I presume) thought that maybe he wouldn't go national because of her.