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To: neverdem
I've been looking for this study I read about a couple of weeks ago from France that showed cannabis in the test showed it could inhibit and reverse hepatic fibrosis. If I recall the study correctly, the cannabis attached itself to the CB1 receptor and acted as an antagonist reducing the effects of fibrosis.

They also used Sativex in the study and it wasn't as effective and the discussion I read centered on the ethanol content. I don't care if a beer has 50 time more ethanol, by your reported study, any ethanol/alcohol content for a cirrhotic liver isn't therapeutic.

Why the hell did GW Pharmaceuticals insert the ethanol into Sativex in the first place?
52 posted on 07/08/2006 10:29:37 AM PDT by bigfootbob
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To: bigfootbob
I've been looking for this study I read about a couple of weeks ago from France that showed cannabis in the test showed it could inhibit and reverse hepatic fibrosis. If I recall the study correctly, the cannabis attached itself to the CB1 receptor and acted as an antagonist reducing the effects of fibrosis.

Copy and paste marijuana and hepatic fibrosis into the query box at PubMed. Maybe that first link was the study that you saw, but check the others.

They also used Sativex in the study and it wasn't as effective and the discussion I read centered on the ethanol content. I don't care if a beer has 50 time more ethanol, by your reported study, any ethanol/alcohol content for a cirrhotic liver isn't therapeutic.

Here's the statement from the first link in comment# 37:

"SATIVEX®contains approximately 50% v/v of ethanol. Each dose contains up to 0.04 g of ethanol. The median daily dose of 5 sprays would be up to 0.2 g ethanol."

It is an excerpt from Sativex's PRODUCT MONOGRAPH for Canada. That was from the cached HTML version of the original Sativex portable data file(pdf) document. It appears to be the equivalent of the product information insert provided with prescription medicines in their original packaging in the USA.

I found it and the amount of ethanol in a standard drink because I thought that the relative and absolute amount of ethanol was relevant.

As an aside, it's my experience that excerpting the relevant statements from either original pdf or cached HTML articles is a reliable pain in the butt.

Why the hell did GW Pharmaceuticals insert the ethanol into Sativex in the first place?

Governments usually won't approve anybody smoking anything, and ethanol is a great organic solvent.

Full disclosure: I'm a physician. My undergraduate major was chemistry. I'm limited in doing literature searches and using the internet as I have had no formal training in either. I had an informal introduction to the internet at a local library six years ago. I originally started searching Medline on CD-ROM over a decade ago. Now I go to PubMed to find citations in the medical literature all the time. Understanding how to use the Boolean operators, AND, OR, NOT greatly facilitates using PubMed. P.S. At PubMed, it's my experience that you don't have to capitalize and, or and not. If you use any other service/function of the National Center for Biotechnology Information, I would capitalize.

53 posted on 07/08/2006 2:50:02 PM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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