Midnight's better.
I once ran 10 liters of a high cell density bacterial culture (80 g dry weight per liter, IIRC) through a French Press and got 10 liters of coagulated mess. It took a gram of purified DNAase and an hour to reduce the viscosity to a point where I could work on the proteins. It was so viscous that it couldn't be stirred conventionally and I had to use a stick. I cackled every step of the way.
That sounds awful!
I was actually after the DNA, lots of it. It wasn't my lab so I couldn't get in there at midnight, although that probably would have worked better when I was trying to amplify one plasmid with chloramphenicol. I never got it to work on a reasonable schedule.