If the states (or individuals) object to Congress regulating intrastate activities such as growing wheat, or private pilots, or recreational drugs, or guns near schools, certainly there are better ways of resisting Congress other than intentionally engaging in these illegal intrastate acts?
Oh, and I doubt that Washington was directing his remarks to that small minority who, unable to legitimately sway public opinion, take matters into their own hands and subvert constitutional Congressional regulatory efforts. That's not resisting "the spirit of innovation upon its principles" -- that's anarchy, pure and simple.