I have a concern that the first h2h2h2h mutations will take place in Africa. Many rural people die of the odd disease all the time, without being seen by anyone except the village healer...
If the feared mutation(s) take place in rural Africa, it could get a foothold there, and move outward.
My plan is to totally isolate and when I'm convinced the H2H mutaion has occurred, I'm going 'underground' (so to speak).