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Really, not knowing or understanding the role of transposon like elements with McClintock being the person who discovered them is indicative of an inorance of basic chromosome structure anf function. This is in regard to either disease or evoltionary considerations.

To make it even more clear I have referenced a couple papers, one by McClintock in 1984 and the other a 20 year retrospective of that paper.

McClintock studied chromosome structure and function and in doing so was able to discover "jumping genes" as they are called. It is now known that these type of DNA are a huge component of the genomes of higher organisms. Their properties wherein they are asssociated with double strand breaks of DNA, translocations, rearrangement, transpsositions and the like provide a mechanism for the differences in chromosomes seen between various species.