None whatsoever, in that it's a philosphical libertarian approach to writing laws, having no connection to history or reality.
BUT, if you buy into it, MrLeRoy's job to convince you to legalize his precious drugs is that much easier.
Reduce them to chewing and swallowing the stuff ~ no smoking allowed or it's a Richard Pryor "head trip" first ~ running downhill with their hair on fire sort of thing.