Selectively. I think in the case of DeWine, we can---and I will---register non-votes and if he loses, so what? His pro-amnesty, anti-ANWAR votes would not be different with Brown in there. However, if the SENATE were in danger of flipping---as bad as it is---I would hold my nose. I think the proper strategy is to selectively target RINOS and send a message to the others to straighten up. We know it's possible: from the time DeWine came in until last year, he was as solid a conservative vote (regardless of what he 'felt') as there was. But 2004 seems to have "freed" him to drift leftward, and it is that behavior we must identify and punish.
No, I do NOT advocate across-the-board handing the country over to the Dems. But there are proven ways to enforce party discipline by unelecting selective menbers.