I am going to assume Mr Lowery has his tongue drilling a hole thru his cheek on this one. Unfortunately there is a segment of Freeprs who will think this marvelous advice. There are Know Nothings alive and well in modern Politics.
Isolationism would be perfectly feasible for the US. We have a large country with lots of natural resources, and a skilled population. We could make everything we need ourselves. The only thing that might give us pause is oil and energy.
This would, of course, cause somewhat higher prices and a lower standard of living. However, many of our problems are caused by being too rich for our own good, and we might benefit by cutting back a little.
However, this is probably not going to happen.