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Physician Advocates for Medical Marijuana
Rutland Herald ^ | Feb. 26, 2006

Posted on 02/26/2006 7:55:05 AM PST by Wolfie

Physician Advocates for Medical Marijuana

Vermont -- As he opened his remarks about medical marijuana, Dr. Joseph McSherry said he couldn't be as informative as he would like to be.

"I asked a very good friend, who happens to be a medical marijuana patient, what I should tell you today," McSherry said. "He said to tell you not to ask a doctor. Doctors don't know (expletive) about medical marijuana."

McSherry, a neurophysiologist and PhD associated with Fletcher Allen Medical Center and the University of Vermont, said his friend is largely correct: There have been few scientific studies on the effects of marijuana as a medicine, and even less research has been conducted on its medical effects in humans.

"You'll probably be more educated than your doctor by the time we get through," McSherry told his audience at the Godnick Center in Rutland on Friday.

He walked the audience through the limited medical data on cannabis and the properties of the chemicals in marijuana other than THC that can have beneficial effects.

Canabanoids, McSherry said, can boost the effectiveness of other painkillers, inhibit the growth of tumors and alleviate wet macular degeneration, which causes blindness in some cases.

"We're just beginning to scratch the surface of this iceberg," he said.

McSherry said that inhaled marijuana can be very effective at treating sudden swift pains, while many other painkillers, including marinol — a legal prescription drug that is a capsule of THC in sesame oil — can take too long to take effect.

"I don't approve of smoking for anybody," he said. "There's got to be a better way of doing it, but the U.S. government hasn't been interested in doing any research.

"If you eat it, the chemicals peak in two to four hours. Eating it is probably the worst way of intaking THC," he said. "If you inhale it, THC levels peak in a few minutes and it actually goes away in the first hour."

He noted that researchers in other countries are trying to develop different types of medical cannabis for patients.

Two members of the audience who said they use the drug for medicinal purposes offered compelling testimony about its benefits. Neither identified themselves.

The first patient said that at one point he had been on 17 different medications to treat his multiple sclerosis — some to counteract the side effects of other medications.

"Now I think I'm on four medications now," he said. "I'm not on medications for the side effects of medication. I'm not drugged out or high. From 17 meds, down to four."

A second patient said he had lost more than 50 pounds while undergoing chemotherapy before using marijuana to counteract the nausea.

"I went from 236 pounds down to 176," he said. "Part of the problem was the sickness of chemo. I couldn't hold down food, and marinol did not work for me. Cannabis did work."

Members of the audience had many questions about medical marijuana, from its chemical properties to the intricacies of growing plants to use for medicine.

"If you have a seed that has a known history of consistent product, you will get a consistent product medically," McSherry said. "That's why I think patients ought to be able to grow their own."

One audience member wondered how patients who don't grow it can access medical marijuana.

"Where does the pot come from if you're not a green thumb person?" she asked.

McSherry said "compassionate clubs" have formed in California that allow medical marijuana patients to bring in prescriptions to be filled with marijuana of a known quality rather than forcing patients to rely on what they can find on the black market, he said.

"In Vermont, if you have a friend or a grandson … you can make a provision to register with the state that you're a registered patient and they're a registered grower," he said, adding that Vermont's medical marijuana law does not shield users or growers from federal prosecution.

McSherry sees access to the drug as an uphill battle. He said many doctors are resistant to the notion of medical marijuana.

"There are very definitely a lot of doctors who are very adamant it's not a medicine," he said. "There are doctors that believe if it were a medicine, the FDA would approve it and pharmaceutical companies would make cannabis that you can take as a product.

"But patients' definition of a medicine is a different thing," he added.


TOPICS: Culture/Society; US: Vermont
KEYWORDS: marijuana; medicalmarijuana; wod; wodlist
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To: patton
"Starting with a tobacco seed, and eventually producing a cigarette, is hard. That is why PM makes money, and the product is so heavily taxed.

Starting with a MJ seed, and eventually producing a joint, is so easy that stoned people do it it all the time.

So...how are you going to tax it?"

What makes you think it's so much harder to produce dried and cured tobacco than it is to produce dried and cured marijuana? People aren't going to want to grow their own pot anymore than their going to want to grow their own tobacco or brew their own beer. It takes time and money, requires growing space, gardening skills, knowledge about the process, and lot's of work to grow high quality marijuana. Most people won't have the growing space or be ambitious enough to learn the skills and do all the work involved. For most it will be like it is for those like me who have brewed beer, something people do once or twice and never again because they realize how much of a pain in the neck it is and how it isn't nearly as easy as it sounds like it is going to be to get good results. Most who smoke pot don't even need nearly as much as they would get in a crop anyway. Most would be just tickled to death if they could pop on down to a licensed shop and select from a wide variety of product on the shelves. Commercial growers would be able to produce consistent smooth smoking high quality product with tastes and aromas pot smokers appreciate and pretty soon people would have favorite varieties or brands that they stick with, and they'll have no more interest in homegrown some yahoo grew in his back yard than they down in homebrew some yahoo brewed in his closet. Production costs could be much lower if the product was mass produced with modern agricultural methods and overall costs would be lower without all the middle men and risks currently involved in bringing the product to consumers. There would be a lot of room for tax without encouraging a black market.
141 posted on 02/26/2006 5:57:44 PM PST by TKDietz
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To: dread78645
Wow, what a great reference! I used the search engine on the site. Washington almost always refers to hemp along with flax, or as a descriptor, as in hempen reins or cord. He also refers to it as an agricultural commodity. The search engine brings up only 38 mentions.

There is no evidence here that he used hemp, or cannabis, to get high. Separating male and female plants has more to do with breeding and cordage; it is not evidence that he was trying to make more "potent" plants.

On FR a year or so ago there was a proponent of using hemp as a fiber, who brought up Washington's hemp acreage, and strongly made the point that hemp is not MJ and cannot be used to get high!

If he did smoke weed, you'd think he'd have written about it once or twice.

Likewise if his household used cannabis as medicine, it would have been in herbals of the day or stored among his effects, or mentioned in doctor's notes. Laudanum is mentioned, but never cannabis as medicine. At his museum, a medical kit has laudanum and even nux vomica bottles, but no cannabis preps.

It may seem odd to a proponent of cannabis, but it looks like he grew it for fiber and rope and never considered getting high from it, unless he kept it a deep secret, which would be odd for something that would not become illegal for a century or more in the future.

If you can find a validated historical document stating that Washington shared MJ as a drug I'll reconsider There are many references to ale and whisky- he had one of the biggest distilleries in the New World- but to my knowledge never a reference to smoking or eating his hemp crops.
142 posted on 02/26/2006 6:34:06 PM PST by DBrow
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To: DBrow

The History of Medical Marijuana

2727 BC First recorded use of cannabis as medicine in Chinese pharmacopoeia. In every part of the world mankind has used cannabis for a wide variety of health problems.

1937 Cannabis withdrawn from the American public against the advice of the medical community. Hemp excluded from "Class II" drugs (having demonstrated medical value) by Nixon administration in 1970. Dispite all evidence to the contrary, hemp was retained as Class I by the Bush administration in 1989.

http://paranoia.lycaeum.org/marijuana/medical/timeline


143 posted on 02/26/2006 6:45:40 PM PST by Supernatural (Lay me doon in the caul caul groon, whaur afore monie mair huv gaun)
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To: DBrow

...In 1762, "Virginia awarded bounties for hempculture and
manufacture, and imposed penalties upon those who did not
produse it."

George Washington was growing hemp at Mount Vernon three years later--presumably for its fiber, though it has been argued that Washington was also concerned to increase the medicinal or intoxicating potency of his marijuana plants.*

The asterisk footnote:* The quality or quantity of marijuana resin (hashish) is enhanced if the male and female plants are separated *before* the females are pollinated. There can be no doubt that Washington separated the males and the females. Two entries in his diary supply the evidence:

May 12-13 1765: "Sowed Hemp at Muddy hole by Swamp."
August 7, 1765: "--began to seperate (sic) the Male from the Female Hemp at Do--rather too late."

The Book of Grass: An Anthology of Indian Hemp_ (1967), says that Washington's August 7 diary entry "clearly indiactes that he was cultivating the plant for medicinal purposes as well for its fiber." [7] He might have separated the males from the females to get better fiber--his phrase "rather too late" suggests that he wanted to complete the separation *before the female plants were fertilized*--and this was a practice related to drug potency rather that to fiber culture.

http://www.erowid.org/plants/cannabis/cannabis_history2.shtml


144 posted on 02/26/2006 6:54:35 PM PST by Supernatural (Lay me doon in the caul caul groon, whaur afore monie mair huv gaun)
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To: Know your rights
Delta-9 THC is burned up quickly, but 11-hydroxy-tetrahydrocannabinol and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol linger for a while. There are more psychoactives in cannabis than just D-9.

There is a body of literature that contradicts your opinion, some of which I post below. If you are correct, and you may be, there must be an effort to refute the erroneous conclusions in the literature today.

A physician, or for that matter, a lawmaker, will be influenced by a peered journal than by a citizen that claims, no matter how sincerely, "but everyone knows..."

That's why I have been talking about conducting new research, specifically to look at medical use.

Do you have references to back up your point, which I think is, Delta 9 THC and other psychoactive compounds leave the body quickly, and the metabolites have no psychoactive potential- right? That's important because many papers state differently.

....................
http://www.psychiatrictimes.com/p020261.html

(this one differentiates)

The fact that 40% of subjects who had used marijuana regularly for an average of 22 years did not report experiencing severe withdrawal symptoms during abstinence might suggest that physical dependence on marijuana is not as strong as that observed with other drugs of abuse. This may be due, at least in part, to the long half-life of THC. However, many subjects reported that when trying to remain abstinent in the past, the presence of withdrawal symptoms had played an important role in their relapse. Thus, alleviation of abstinence symptoms may contribute to the maintenance of daily marijuana use in chronic users.
................
http://science.howstuffworks.com/marijuana4.htm

(does not differentiate between isomers)

The initial effects created by the THC in marijuana wear off after an hour or two, but the chemicals stay in your body for much longer. The terminal half-life of THC is from about 20 hours to 10 days, depending on the amount and potency of the marijuana used. This means that if you take one milligram of THC that has a half-life of 20 hours, you will still have 0.031 mg of THC in your body more than four days later. The longer the half-life, the longer the THC lingers in your body.

.......................
http://www.idmu.co.uk/drugtestcan.htm

(does not differentiate between types of THC)

2.1 Pharmacokinetics is the study of the time course of how drugs are distributed in the body, how long the effects last and how such effects relate to drug tests.

2.2 The major problem with measurement of metabolites is the very long detection times, owing the the rapid deposition of cannabinoids in inert fatty tissue following administration. Johannson et al[3] reported that total amount of THC metabolites and the levels of delta THC-acid could be followed up to 25 days after abstinence using EMIT cannabinoid assay and HPLC.

2.3 The residual level of THC in the bloodstream occurs when THC is released from the adipose (fatty) tissues, where it is deposited shortly after smoking. THC is also converted to its inert acid form within minutes of ingestion[4]. The half-life of THC in fatty tissue is approximately 8 days[5][6]. There is little evidence that clearance rates for THC differ significantly between naive and experienced cannabis users.
145 posted on 02/26/2006 6:55:33 PM PST by DBrow
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To: Supernatural
Sorry in advance for length.

I'd expect to see in his financial papers sale of hashish or cannabis leaf, or a mention where he explicitly says that hemp grown one way is more medically strong than another way. There also is no evidence he or his household used hemp medicinally- it was uncommon at the time.

Merely separating the plants is not evidence that he even considered the potential to use it to get high. Separating males from females prevents monoectic plants, as described below. Also, male stalks were used for one purpose, and females for another, so Washington separated the two for this reason.

http://www.innvista.com/health/foods/hemp/hempbiol.htm

Fiber Types

Total fiber content is approximately 25-35% of the stem dry matter, depending on the variety.

* Primary bast fiber – long and low in lignin

* Secondary bast fiber – intermediate and high in lignin

* Libriform – short and high in lignin

According to Dr. Ivan Bocsa, industrial fiber varieties can be classified into two basic sexual types: monoecious and dioecious. Monoecious varieties have both male and female flowers on each plant, while Dioecious varieties have entirely separate male or female plants.

The dioecious trait is the natural condition for hemp while monoecism occurs infrequently in hemp populations. The incorporation and stabilization of monoecism in fiber hemp call for the skills of a competent plant breeder. It was a Russian hemp breeder who first recognized the utility of monoecism in solving two of the plant’s critical problems: low seed yield and uneven maturation of the sexes.

Monoecious hemp varieties require yearly selection to prevent the increasing return of separate male and female plants (dioecism) over successive generations of open-pollinated seed production. Also, because seed from successive reproductions gives progressively lower seed yield in the dual-purpose (fiber and seed) monoecious crop, it is customary to label monoecious hemp seed according to the number of generations that have been grown since a new supply of seed was obtained from the breeding source.

........................

Stalks

Hemp stalks are dependent upon two things: the sex of the hemp plant and how closely they are planted together. Male stalks are generally 10-15% taller than female stalks, even though the female vegetative period is 6-7 weeks longer. Stalks planted in close proximity to each other average 4-8 inches and increases as available area increases. Male plants also have thinner stalks while female stalks are shorter and thicker.

Historically, farmers pulled up male plants on their small plots separately from the female plants and used the male plant fibers for fine linens (bedding, hand towels, and clothing). The female plant fibers were used to make coarser fabrics (bags and tarp). Today, precise tests reveal that male plants surpass female ones in all qualitative parameters except tensile strength. Common fiber hemp in a mixed plot takes a median position between both sexes. In terms of quality, its fibers are closer to male fibers than female fibers.

When separated from the roots and leaves, the stalk constitutes about 65-70% of the total mass of a fully grown plant. If fiber hemp is densely sown, the leaves fall off during the developmental phase and tiny calluses form at these points. The crop loses most of its leaves, and fiber hemp does not have many branches. However, the area available for one plant to expand is two square feet; meaning roughly five plants per square meter or a 3-foot square plot.

.....................

If medical cannabis is to become accepted by the voter, a better argument than "George Washington and the Chinese used it to get high" should be used, don't you think?

Doctors and hospital administrations must be convinced it's a good idea, then they can lean on the politicians.

An interesting side note- what becomes possible when three quarters of the States all pass medical marijuana laws? So working to get good people in the House is important.

146 posted on 02/26/2006 7:17:34 PM PST by DBrow
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To: Supernatural

The Chinese don't allow cannabis as medicine now- why did they stop? What did these wise people learn?

They also, with the help of Great Britain, used lots and lots of opium. That does not make it a good idea now, just because they used to do it.

Yup, people die from opium withdrawal. And cannabis, like DDT, has never killed anyone (except perhaps for momentary lapses of reason leading to accident or mishap, but ethanol, salvia, and LSD can lead to that too).


147 posted on 02/26/2006 7:21:05 PM PST by DBrow
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To: DBrow

People keep bring up other drugs. Let's stick to MJ, OK? Not opium, not LSD, not cocaine, not heroin. Unless you want to compare how deadly they are as compared to MJ.

DDT was banned because it was having an effect on the amphibian population and the bird population. That was being passed up along the food chain.

Heck, water has killed people and I don't mean by drowning. From drinking too much of it. It is rare but it has happened.

No one ever died from using marijuana. That's the bottom line. If it is that safe, why is it illegal? That is the big question. Many substances that actually are very dangerous are legal. What is the criteria to make a substance legal and other substances illegal? Their potential lethality? What?

Why should such a benign substance be illegal? Inquiring minds want to know. Just because the government says so is not a good enough reason for many people, including me.


148 posted on 02/26/2006 7:34:26 PM PST by Supernatural (Lay me doon in the caul caul groon, whaur afore monie mair huv gaun)
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To: HangnJudge
Bad idea

I agree. But why isn't marijuana in the pharmacopeia, where it resided happily, if minimally uselful, for lo those many centuries?

My vote? Make it a prescription drug. It certainly cannot be any more or less useless than many other prescription drugs. You know the drill: "Do not operate heavy machinery, etc. etc."

149 posted on 02/26/2006 8:36:43 PM PST by Kenny Bunk (Safer to hunt with Dick than ride with Ted.)
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To: zakbrow
Why do we as a country keep spending money on something that doesn't work?

Politics, keeping the constituency happy by showing them there is a war against drugs. Sick, isn't it?

150 posted on 02/26/2006 8:37:07 PM PST by celestine phophesy (One who asks a question is a fool for 5 min; one who does not ask a question remains a fool forever.)
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To: TKDietz

That sounds like a really good plan forward!


151 posted on 02/26/2006 8:38:17 PM PST by celestine phophesy (One who asks a question is a fool for 5 min; one who does not ask a question remains a fool forever.)
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To: HangnJudge

Maybe it is a bad idea... but why is that any concern of yours? Why should it not belong in the hands of the patient and his doctor? Or just the patient, for that matter? Where do YOU get off telling another American what he or she is allowed to put into his or her own body? Please explain that. Then explain just EXACTLY where in the Constitution for the United States such authority was ever granted to the Federal government. Remember the Ninth and Tenth amendments, when you are doing this.

And if you really are a judge (and not just playing one on FR) you should be IMMEDIATELY removed from the bench if you hold that attitude in real life.


152 posted on 02/26/2006 9:52:18 PM PST by dcwusmc ("The most dangerous man, to any government, is the man who is able to think things out for himself.)
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To: SandfleaCSC

No. She left you because you turned into a bat.


153 posted on 02/27/2006 5:40:56 AM PST by robertpaulsen
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To: Supernatural
"George Washington grew vast amounts of MJ on his plantation. So did Thomas Jefferson."

Yeah, they grew hemp. They also owned slaves. What's your point?

Are you suggesting we use slaves to grow dope, just because Washington and Jefferson did? I don't think that would be constitutional. (Though the way you read the constitution, it may be.)

154 posted on 02/27/2006 5:51:47 AM PST by robertpaulsen
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To: Supernatural
August 7, 1765: "--began to seperate (sic) the Male from the Female Hemp at Do--rather too late."

George Andrews has argued, in _The Book of Grass: An Anthology of Indian Hemp_ (1967), that Washington's August 7 diary entry "clearly indiactes that he was cultivating the plant for medicinal purposes as well for its fiber."

George Washington didn't grow India hemp (not Indian hemp) until the 1790's. Prior to that he grew English hemp which couldn't be smoked no matter how many times you separated the males.

"Began to separate the Male from the Female hemp at Muddy hole ¾ rather too late... [7 Aug.]"

"The English Hemp i.e. the Hemp from the English seed was picked at Muddy hole this day 7 was ripe. Began to separate Hemp in the Neck... [15 Aug.]

155 posted on 02/27/2006 6:41:05 AM PST by robertpaulsen
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To: dread78645
"The artificial preparation of Hemp" -- Hashish?"

Washington was referring to a hempseed soup stock made in Silesia (an area between Germany and Poland).

Not "sinse", not "hashish".

156 posted on 02/27/2006 6:57:05 AM PST by robertpaulsen
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To: robertpaulsen

Yeah, they grew hemp. They also owned slaves. What's your point?

Are you suggesting we use slaves to grow dope, just because Washington and Jefferson did? I don't think that would be constitutional. (Though the way you read the constitution, it may be.)

You are a very, very lucky man. Luckier than you will ever know. Color yourself lucky.


157 posted on 02/27/2006 7:01:21 AM PST by Supernatural (Lay me doon in the caul caul groon, whaur afore monie mair huv gaun)
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To: DBrow
Do NOT confuse MrLeRoy with the facts. He hates that.
158 posted on 02/27/2006 7:13:24 AM PST by robertpaulsen
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To: robertpaulsen

No one ever died from using marijuana. That's the bottom line. If it is that safe, why is it illegal? That is the big question. Many substances that actually are very dangerous are legal. What is the criteria to make a substance legal and other substances illegal? Their potential lethality? What?

Why should such a benign substance be illegal? Inquiring minds want to know. Just because the government says so is not a good enough reason for many people, including me.


159 posted on 02/27/2006 7:17:16 AM PST by Supernatural (Lay me doon in the caul caul groon, whaur afore monie mair huv gaun)
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To: Ken H
I was hoping that independent and impartial group, the Soros-sponsored Marijuana Policy Project, would have phrased the question differently. Something like:

QUESTION: Do you think adults should be allowed to grow and smoke marijuana for medical purposes if they visit a certain doctor complaining of some kind of pain and that doctor recommends it, or do you think they should be thrown out of the doctor's office and told to go out and find a job?

160 posted on 02/27/2006 7:20:18 AM PST by robertpaulsen
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