Granted, their most vocal opponents are rationally inconsistent. (A group that was staunchly pro-life and opposed to the brutal treatment of animals would defy all praise.) But being "kooky" or "flakey" doesn't mean they're wrong.
There are respectable scientists who maintain that these experiments are needless. God made us stewards of our animal companions. That does not mean we can torture them to death.
"God made us stewards of our animal"
God gave us dominion over animals and we are not to worship them.
When people start placing animals above people, its time to start reaccessing their priorities, IMO.
When people buy animals they are their property and it is none of my business what they do with them.