A little over 40 years ago an acquaintance of mine gave me some DMT (that's what he said it was anyway). It was a waxy, brown substance kind of like beeswax. He said to blend it with tobacco and smoke it. I did this and was struck first by its pungent and rather awful stench and second by the lack of immediate effect. I was in the middle of my 4th inhalation when I felt a very pronounced vibration start in my feet and move steadily and quickly up to my head. When it reached my head my surrondings appeared to vibrate and colors intensified so that objects seemed to be glowing. Hearing became very sensitive as well. The effect lasted about 10 minutes. I have no idea what the effect would be if it is ingested rather than inhaled. A couple of years later I read that DMT was thought to cause pinpoint brain hemmorhages (no doubt explains much about my behavior over the past 4 decades).
Oral ingestion of DMT does nothing, your stomach enzymes destroy it- unless you mix the DMT with another drug that's an MAO inhibitor, then the enzymes are deactivated for long enough that the DMT passes into hte blood. Smoking "pure" DMT lets it pass into the blood through the lungs.
I find it fascinating that the original users of ayahuasca found this somehow and exploited it. It must have come froma culture with a strong drive to find psycoactives, I doubt it was an accident given the reported taste and appearance of the mixture.
Ayahuasca and huasca both use a DMT-containing plant like psychotria viridis mixed with an MAOI plant like bannisteria or peganum harmala.
And I marvel that the folks would deliberately drink something that made them so sick last time they tried it.
When I drink the wine and eat the broken bread in church, I don't get sick, I just remember the Last Supper and sacrifice and redemption.