If that is larger than $1, then, on average, you can expect to win more than you lose. (Unfortunately, you also have to account for the probability of sharing a jackpot, which goes up with large payoffs.)
The odds of winning are so slim, that you really shouldn't take out a second mortgage to play all possible numbers.
This happened once, though. I can't find the story, but Voltaire and some philosophes at the time essentially purchased all possible winning numbers.