Warning #1: The end with the big round hole must be pointed downrange.
I have that type of Glock in question and I reload for it, I'm willing to bet the case has been overused and got thin, also the Glock barrels do leave a portion of the case exposed that can case a rupture especially if its a hot load. I did buy an aftermarket barrel that drops in and uses the .45 case but is necked down to become a .400 CORBON.
A .45 recoil isnt bad really but I use the Glock 10mm as my personal protection. My favorite though is the single stack SIG P220 .45 very nice built.
I have several 9mm but recently I have felt the need to have more stopping power and more rounds aviable like double stack mags. Hi cap .45 mags are a bit wide for a small handed person and having only 8 rounds is just not safe insurance especially if you have crazed multiple assailants.
best round for a woman, .357 SIG for a guy that can handle recoil a good 10mm. Glocks are good cause they are ready to fire right then and are simple simple firearms.
Buying a .50AE or anything else of the super macho handguns is asking for big trouble, the rounds are hard to manage unless you have the strength, the round which if you miss your target and you most likely will, have tremendous collaterial damage such as penetrating walls and such.