Replies

Sounds like an effective, cheap, preventative.

It'll be banned like red yeast rice was banned because it lowered cholesterol levels naturally.

Even if this were true it still wouldn't be worth it.

reckon Dave Lister was onto something. he lived for a long time...

Sounds like an effective, cheap, preventative.

Sounds like crap. There are a thousand other things I'd rather eat. However, when I think of life in a hospital bed, I guess it's worth acquiring a taste for this kind of thing.

Lemon Curry?

I have a great recipe for cauliflower curry. Maybe I'll make it next week!

Yeah...but is it worth smelling? I dunnno? It seems like there are other preventative means without smelling like an Indian Food Restaraunt 24/7/365.

If cancer is what it takes to avoid eating that stuff, so be it.

I see no reason to live miserably in order to live longer.

The article doesn't exactly say, but what am I supposed to do with the curry?

Owl_Eagle

(If what I just wrote makes you sad or angry,

it was probably sarcasm)

This Curry will give you a free prostate exam as well..

I lived in England in the 70's. The only thing open after the pubs closed was Indian restaurants. I loved the spiciest Vindilu (sp) curries. They would create a hostile environment in my colon that I almost died from. I'm not surprised that pathogens can't live there either.

Cool, thanks for posting this.

I can certainly understand the anti smelly vegetable lobby, though I happen to like them myself.

On a more serious note, after watching my father, my uncle, and the fathers of three friends go through that disease, I'd eat gravel with algae sauce if I thought it would prevent that.

From what I've read, research on phytochemicals is real and very promising. Someday they'll probably synthesize the active ingredients and sell them as a drug for $100 a month, subsidized by Medicare of course. I'd rather just eat the stuff, though it is an aquired taste.

I use cauliflower for mashed potatoes.....YUM.....and even others find them not too bad.

Yum! I love curry! I believe it is an acquired taste for most people though. Another problem is curry is like alcohol in that you can smell it when you sweat it out of your body.

Sounds yummy to me. I like everything listed, especially curry. I'm not a very picky eater except that hot food needs to be served hot and cold food cold.

I have always said...broccoli cures cancer. I eat a good portion every day.

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Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient MiceTin Oo Khor^1,2, Young-Sam Keum^1,2, Wen Lin^1,2, Jung-Hwan Kim^1,2, Rong Hu^1,2, Guoxiang Shen^1,2, Changjiang Xu^1,2, Avanthika Gopalakrishnan^1,2, Bandaru Reddy^1,3, Xi Zheng^1,3, Allan H. Conney^1,3 and Ah-Ng Tony Kong^1,2

¹ Center for Cancer Prevention Research, ² Department of Pharmaceutics, and ³ Susan Lehman Cullman Laboratory of Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey

Requests for reprints: Ah-Ng Tony Kong, Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Freilinghuysen Road, Piscataway, NJ 08854-8020. Phone: 732-445-3831; Fax: 732-445-3134; E-mail: kongt@rci.rutgers.edu .

Earlier studies using prostate cancer cells in culture showedthat phenethyl isothiocyanate (PEITC) and curcumin have significantchemopreventive and possibly chemotherapeutic effects. However,their in vivo effects are still lacking. Hence, this study wasundertaken to determine the possible in vivo efficacy of prostatecancer-prevention as well as cancer-therapeutic treatment byPEITC and curcumin alone or in combination. We evaluated theeffects on tumor growth in vivo, using NCr immunodeficient (nu/nu)mice bearing s.c. xenografts of PC-3 human prostate cancer cells.Molecular biomarkers representing proliferation and apoptosiswere determined. Continued i.p. injection of curcumin or PEITC(6 and 5 µmol; thrice a week for 28 days), beginning aday before tumor implantation significantly retarded the growthof PC-3 xenografts. Combination of i.p. administration of PEITC(2.5 µmol) and curcumin (3 µmol) showed strongergrowth-inhibitory effects. Next, we evaluated the cancer-therapeuticpotential of curcumin and PEITC in mice with well-establishedtumors, and the results showed that PEITC or curcumin alonehad little effect, whereas combination of curcumin and PEITCsignificantly reduced the growth of PC-3 xenografts. Immunohistochemistrystaining and Western blot analysis revealed that the inhibitionof Akt and nuclear factor- ${kappa}$ B signaling pathways could contributeto the inhibition of cell proliferation and induction of apoptosis.Taken together, our results show that PEITC and curcumin aloneor in combination possess significant cancer-preventive activitiesin the PC-3 prostate tumor xenografts. Furthermore, we foundthat combination of PEITC and curcumin could be effective inthe cancer-therapeutic treatment of prostate cancers. (CancerRes 2006; 66(2): 613-21)

Curry and Cauliflower Could Halt Prostate Cancer

Rutgers researchers have found that the curry spice turmeric holds real potential for the treatment and prevention of prostate cancer, particularly when combined with certain vegetables.

New Brunswick/Piscataway, N.J. - infoZine - The scientists tested turmeric, also known as curcumin, along with phenethyl isothiocyanate (PEITC), a naturally occurring substance particularly abundant in a group of vegetables that includes watercress, cabbage, winter cress, broccoli, Brussels sprouts, kale, cauliflower, kohlrabi and turnips. "The bottom line is that PEITC and curcumin, alone or in combination, demonstrate significant cancer-preventive qualities in laboratory mice, and the combination of PEITC and curcumin could be effective in treating established prostate cancers," said Ah-Ng Tony Kong, a professor of pharmaceutics at Rutgers, The State University of New Jersey.

The discovery was announced in the Jan. 15 issue of the journal Cancer Research by Kong and his colleagues at Rutgers' Ernest Mario School of Pharmacy.

Prostate cancer is the second leading cause of cancer death in men in the United States, with a half-million new cases appearing each year. The incidence and mortality of prostate cancer have not decreased in past decades despite tremendous efforts and resources devoted to treatment. This is because advanced prostate cancer cells are barely responsive even to high concentrations of chemotherapeutic agents or radiotherapy.

The authors noted that in contrast to the high incidence of prostate cancer in the United States, the incidence of this disease is very low in India. This has been attributed to the dietary consumption of large amounts of plant-based foods rich in phytochemicals - nonnutritive plant chemicals that have protective or disease-preventive properties.

Consequently, scientists have been investigating intervention options based on compounds found in edible and medicinal plants. They have had some success, and a majority of patients with prostate cancer are now combining the conventional therapies with these compounds as alternative, supplementary or complementary medications.

For Kong's study, researchers used mice bred so that their immune systems would not reject foreign biological material and injected the mice with cells from human prostate cancer cell lines to grow tumors against which the compounds could be tested.

"Despite convincing data from laboratory cell cultures, we knew little about how PEITC and curcumin would perform in live animals, especially on prostate cancer," Kong said. "So we undertook this study to evaluate how effective PEITC and curcumin might be - individually and in combination - to prevent and possibly treat prostate cancer."

The researchers injected the mice with curcumin or PEITC, alone or in combination, three times a week for four weeks, beginning a day before the introduction of the prostate cancer cells. They found the injections significantly retarded the growth of cancerous tumors. Using PEITC and curcumin in tandem produced even stronger effects.

The group went on to evaluate the therapeutic potential of curcumin and PEITC in mice with well-established tumors, and the results showed that PEITC or curcumin alone had little effect, whereas the combination of curcumin and PEITC significantly reduced tumor growth.

The paper, "Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice," is available at cancerres.aacrjournals.org.

The authors are Tin Oo Khor, Young-Sam Keum, Wen Lin, Jung-Hwan Kim, Rong Hu, Guoxiang Shen, Changjiang Xu, Avanthika Gopalakrishnan, Bandaru Reddy, Xi Zheng, Allan H. Conney and Ah-Ng Tony Kong, all from Rutgers. Source: Rutgers, the State University of New Jersey

Curry Spice Plus Cabbage Compound May Fight Cancer

I've also read that curcumin is used for the prevention of melanoma.

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