Well I have no problems if she says yes because she will have my vote. But we could be beating a dead horse on this one which is what I truly think.
I don't think we should put a whole lot of energy into it at this point. The most likely outcome, frankly, is that she will continue to be the "real" President (a position she currently shares with Cheney), and let some figurehead who wants to "be the President" take all the crap that comes along with the official title. She already has as much power as any President in my lifetime. Why put up with all the crap of campaigning, making endless simple-minded speeches at fundraising dinners, dodging flying mud, etc., when you can have all the important stuff without that? She's a smart lady, and certainly smart enough to do that calculation.
The serious decision-time will come a bit further down the road, if the Democrats have finally managed to scrounge up a viable candidate, the early announced Republican candidates are shaky, and there appears to be a real risk of a Democratic White House. At that point, I believe she would do what needs to be done, even if it was determined that what's needed is for her to run, either for President, or (more likely) for VP. If her amazing parents were still alive, I think they'd encourage her to do that, and I think she'll have that in mind when making any big decisions.