Given Ted Kennedy, John Kerry, and this story, Massachusetts must be a very strange state.
Kerry has to choose between White House run and Senate re-election in '08, barring a change in the law that would allow him to run for both. Most likely he'll hope for a Hillary meltdown; if not, he may run in a few primaries, get whooped by Shrillary, then withdraw and concentrate on running for Senate instead.
Yes, Mass. used to have a GOP senator at one time! Ed Brooke. Elected in '66 and '72; defeated in '78 by Paul Tsongas (who left in '84, opening the way for Kerry to grab the seat.)