No it is not a refutation at all.
If 2% of 10,000,000 live births are abnormal that would be
200,000 babies a 78% increase would be 356,000 or an additional 156,000 babies. This is a big difference.
A 78% increase in a rate of return on an investment is a gigantic difference.
This article discusses increased risk...............and the numbers are insignificant when discussing increased risk.
Where did you come up with 2%?