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To: johnnyb_61820

"We now know that many mutations in bacteria are caused because the bacteria decided it needed the mutation. It even has special DNA polymerases to cause specific kinds of mutations, whose use is regulated. "

As a microbiologist, I'd like to know more about this. Please enlighten me, preferably using references.


1,065 posted on 12/31/2005 8:02:31 AM PST by furball4paws (The new elixir of life - dehydrated toad urine.)
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To: furball4paws
DNA PolyIV is used to generate mutations in E. Coli in stress conditions:

Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli

For certain mutations, such as ebgR, it is regulated by PhoPQ:

Adaptive Mutagenesis at ebgR Is Regulated by PhoPQ

1,131 posted on 12/31/2005 1:43:52 PM PST by johnnyb_61820
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