No. And we've shown a marked dislike for Mass politicians, having defeated two in presidential elections since 1970 (Kerry and Dukakis) and several more in Presidential primaries (Tsongas, Kennedy, etc.).
The Republicans, whose polical base is in the South and West would be foolish to nominate a Mass resident, who would be unlikely to even carry his own state in the general election and would likely alienate the base by being too sympathetic to the lefist and socialist policies of his home state.
Jack Black, if you are comparing Romney to Kerry, Dukakis, Kennedy or Tsongas, you need to research the subject. Not the same thing. Apples and oranges, they are on DIRECTLY opposite ends of the political spectrum.
You are correct though, if he runs for president, he is unlikely to carry his home state.