The fact she was not a New Yorker was an issue in 2000, it is a non-issue now. The issue that she isn't interested in completing a 2nd term in order to run for President, however, IS an effective campaign issue. Here's hoping Mayor Spencer will exploit it greatly and offer a clearly different vision for New Yorkers than Hillary or Pirro would offer.
Spencer has less of a chance against Hillary than Lazio had.