Posted on 12/02/2005 4:35:53 PM PST by Jean S
MDMA was around back in the 60's, as one more thing to drop when you got bored with acid, psilocybin, mescaline and diet pills. It wasn't called ecstasy then.
I can't remember what it was called.
I think it was called MDA.
"I can't remember what it was called."
hmmm... side effects?
(kidding)
Parrott, A. C. Department of Psychology, University of East London, London, UK.
Human Psychopharmacology (2001), 16(8), 557-577.
Abstract
MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy was scheduled as an illegal drug in 1986, but since then its recreational use has increased dramatically. This review covers 15 yr of research into patterns of use, its acute psychol. and physiol. effects, and the long-term consequences of repeated use. MDMA is an indirect monoaminergic agonist, stimulating the release and inhibiting the reuptake of serotonin (5-HT) and, to a lesser extent, other neurotransmitters.
Single doses of MDMA have been administered to human volunteers in double-blind placebo-controlled trials, although most findings are based upon recreational MDMA users. The massive boost in neurotransmitter activity can generate intense feelings of elation and pleasure, also hyperactivity and hyperthermia. This psychophysiol. arousal may be exacerbated by high ambient temps., overcrowding, prolonged dancing, and other stimulant drugs.
Occasionally the serotonin syndrome reactions may prove fatal. In the days after Ecstasy use, around 80% of users report rebound depression and lethargy, due probably to monoaminergic depletion. Dosage escalation and chronic pharmacodynamic tolerance typically occur in regular users.
Repeated doses of MDMA cause serotonergic neurotoxicity in lab. animals, and there is extensive evidence for long-term neuropsychopharmacol. damage in humans. Abstinent regular Ecstasy users often display reduced levels of 5-HT, 5-HIAA, tryptophan hydroxylase, and serotonin transporter d.; functional deficits in learning/memory, higher cognitive processing, sleep, appetite, and psychiatric well-being, and, most paradoxically, loss of sexual interest/pleasure.
These psychobiol. deficits are greatest in heavy Ecstasy users and may reflect serotonergic axonal loss in the higher brain regions, esp. the frontal lobes, temporal lobes, and hippocampus. These problems seem to remain long after the recreational use of Ecstasy has ceased, suggesting that the neuropharmacol. damage may be permanent.
...now if it was just used at rock concerts and love-ins it would be ok.
Drugs start out this way all the time. Good intentions and then abuse. If the drug has any potential to get somebody high somebody will go for it.
MDA is not the same as MDMA. They differ by a methyl group.
I find little comfort he is considered an expert on anything.
STP
I thought STP was something else. What the hell, they're all speed when you get right down to it.
I could be wrong but I was taught that STP was MDMA
Yes, it was called MDA.
I seem to remember it as MD-20/20 or "Mad Dog 20/20"
It's also the racer's edge.
You may recall correctly.
bump for later
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