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To: freespirited; Mom MD

Actually, one theory gaining some adherents is that the absence of aspirin use in kids is the CAUSE of the increase in asthma:

Ann Allergy Asthma Immunol. 1998 Oct;81(4):347-51. Related Articles, Links


Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma.

Varner AE, Busse WW, Lemanske RF Jr.

Allergy Diagnostic, Beachwood, Ohio 44122, USA.

BACKGROUND: The prevalence of asthma, atopic eczema, and allergic rhinitis has increased over the last three decades in Western countries. Speculation on the causes of this trend have focused on changes in environmental factors. We hypothesize that the decreased use of aspirin in favor of acetaminophen, due to the association of aspirin with Reye's syndrome during febrile respiratory infections, may be contributing to these trends in the United States. DATA SOURCES: A detailed literature search was conducted utilizing Medline. Studies considered relevant and important involving both humans and animals in English language were used. HYPOTHESIS: In the United States, the documented prevalence of childhood asthma has increased since 1970, but the rate of this increase accelerated upward beginning in the early 1980s when the use of pediatric aspirin decreased. During the resolution of common respiratory viral infections, prostaglandin E2 (PGE2) is produced through the actions of cyclooxygenase-2 (COX-2). Aspirin, but not acetaminophen, inhibits COX-2 activity. As PGE2 promotes TH2 and inhibits THI type cytokine generation, we hypothesize that the decreased use of aspirin may be a factor in facilitating allergic sensitization and asthma by augmenting the relative TH1/TH2 cytokine imbalance in genetically predisposed children. CONCLUSION: We have presented an hypothesis based upon epidemiologic trends, known biologic effects of cytokines and PGE2 on allergic sensitization, and a potentially relevant pharmacologic effect of aspirin to explain a component of the increasing prevalence of childhood asthma in the United States. We suggest this theory be examined further in animal models as well as in other countries where the prevalence of childhood asthma is increasing.


126 posted on 11/26/2005 3:20:42 PM PST by Pharmboy (The stone age didn't end because they ran out of stones.)
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To: Pharmboy

cool article. TKS


129 posted on 11/26/2005 3:22:49 PM PST by Mom MD
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To: Pharmboy

Intersting post.

I too, am baffled with the relatively recent allergic reaction to peanuts.

Hubby and I were in the waiting area of a flight from Missoula, MT. to Milwaukee,WI., and all of the people on our flight were told that one of the passengers on our flight had a peanut allergy, and we were to throw away any items we had on us that contained peanuts before we boarded.

Of course we did ditch our Snickers Bars, but, as many people responding here, I just wonder about the cause of this allergy!


135 posted on 11/26/2005 3:31:37 PM PST by forward (`)
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