Even some of these hormones don't work if used. For example, a lot of fat people are leptin resistant because of the constant high circulating level of leptin in their bodies. You'd have to cut their food intake and let them desensitize to it before it would ever have an effect.
Uh, read this:
We just don't know enough yet to make a pill that will work. That will change, though. We're just getting started.