Without some basic information from your post one has to make assumptions to answer your question. So here are my assumptions:
a. You want a handgun.
b. The handgun is for learning/pleasure (such as plinking).
c. The handgun must be of good quality but inexpensive to shoot.
With those assumptions, I recommend a Ruger .22 Cal Single Six revolver with an interchangeable magnum cylinder. It's a great quality pistol that's not to expensive to purchase and dirt-cheap to fire all day. Also, the hollow-point magnum rounds are potent.
Based on the assumptions, I also like this advice. I would add: See if a local range or gun store offers instruction and various rental firearms for use on the range. Get some instruction and try out all the firearms that you think may appeal to you--this will help avoid a poor choice and will prove to be money well spent.
Start off with the 22/22 magnum or the 38/357. You can move up to the larger calibers when you feel ready.
Over the years, I wish I had done this more faithfully myself.