Club for Growth is doing some targeting for 06. This group is very effective, having supported Coburn and I believe Pence as well. If the GOP wants the money, they better start listening to their conservative base. No more money for RINOs.
You can donate money to the campaigns of conservtive primary challengers through the Club for Growth, I do almost all my political donations this way now, nothing for the sleazy weasels at RNC or associated organs.