Not one issue but unless that issue is addressed the others will not be allowed to assume importance. This is what makes Paul so goofy. While pretending to have a concern about the Constitution he would not allow the government to act in the area in which it is most clearly charged by that Constitution to act.
I happen to feel the same way about 2nd Amendment rights, and certain freepers call me a "one-issue unappeasable" because of it. Then it seems as if these same freepers write Paul off completely because they disagree with his way of handling foreign affairs, even though he is hands-down the best we have when it comes to domestic issues.