Shorten ones lifespan.
In fact, if the people who are lashing out at him would ever listen to one of his interviews they would notice that, when asked this very question, he says that in many respects he's grateful.
If he had been confirmed to the Supreme Court he would not be able to enjoy time with his family, as well as being denied the opportunity to speak his mind-as freely as he desires-on a variety of subjects near and dear to his heart.