Federalist 76 doesn't trump Article 2 any more than Jeffersons letter to the Danbury Bapists is authoritarian in the SCOTUS.
The senate can certainly take it under advisement but Article 2 is pretty clear, cronies are not disqualified for being cronies.
Unless, of course, it is in the penumbra.
We shall see my fine feathered friend. We already know her personal accomplishments are suspect; unless Ms Miers impresses the panel with the carriage, intellect and character expected of the position, the Senators will be left asking one primary question: why (ie on what basis) was this woman nominated? It will then be up to them to perform their constitutional duty in rejecting this nominee, unless, of course, she withdraws her name first.