[Straight Vermonter]

Sorry it's a guestimate from an internet acquaintance (a journalist) who lives in Pakistan. He thinks the damage north of Islamabad will be very serious.

There is a fair sized city there named Muzaffarabad.

[ARealMothersSonForever]

There was a fair sized city. I hope your acquaintance is safe and well.
See Alaska for reference on any quake over 7.0. Magnitude is not linear. If a quake breaks things 400+ mile from epicenter, it is big.

[Strategerist]

There are millions in the area directly above the quake; Muzaffarabad, Abbotabad, Mansehra, etc. There have been no reports from this area at all.

25,000+ killed seems quite plausible to me.

[countyourblessings]

Is your acquaintance in Islamabad? I have family north of Islamabad around Abbatobad in the mountains. I haven't heard anything from them but should soon if their phones are working. I'm sure they will call their parents and the word will be passed on.