It would certainly take the wind out of the sails of the argument that's been repeated ad nauseam here: that Republican Senators have no stomach to fight for a real Originalist nominee.
He has to fill the seat. If 45 democrats and 15 republicans will block his moderate nominee, and if 45 democrats and 7 republicans will block his conservative nominee, he'll have to send up another Ginsberg: who got all but 3 votes.