Causality cannot be falsified. ToE is fundamentally about the assumption that natural selection and variability is the cause of all change.
Causality CAN be falsified, simply by observing another stimulus of speciation and another selective mechanism. Even if such things cannot be observed directly, their effects should be apparently different from those caused by random genetic mutation and selective pressures.
a single example of single-generation saltation between high-order taxa would serve to rock the ToE to the core.