A hot .22 LR JHP placed in the right places will stop anyone. Three rounds in the noggin works every time.
Keep in mind that it is very difficult to reload .22s; the primers are a bitch!
LOL.
Series, 9mm Sigs (P226) stainless steel are my choice for the home.
I carry a Sig .380 (9mm Kurtz) P232 stainless steel when travelling.
For yard work, a Bond Arms stainless steel .357 derringer with snake shot. We have copperheads here in North Carolina. On average, I dispose of two to three every March/April/May season. One time I used the chain saw on the snake next to the fallen tree I was limbing.
I have a snake-eyes that I got for snakes in the woods. It's a side by side .45 officially but .410 fits nice. The shells leave an 1/8 inch of barrel in front of them so the group is not very tight. When there is a 13 inch copperhead slithering in the grass 3 feet from you this takes care of the problem without having to be so accurate as to be able to hit a string. It is now my bedside piece.