Maybe 3 to 4, 10 to 15 kiloton devices in strategic points of the storm to try to disperse its cohesion as a storm...sux we can't do anything but watch it hit...seems like such an action was pondered in the fifties.
A bomb or bombs would be a dead end since the amount of energy a hurricane is releasing and the size of its circulation would make any bomb, including the largest nuclear bomb, seem more futile than trying to stop a charging elephant by throwing a ping-pong ball at it. As noted above, hurricanes release tremendous amounts of heat energy. In fact, since hurricanes are "heat engines" that depend on the temperature contrast between warmth at the ocean surface and cold air aloft, we could wonder whether the heat from any kind of bomb would actually add to the storm's natural heat supply, making the storm stronger. Trying to heat the upper atmosphere with bombs, to lessen the heat contrast, would be like trying to heat the city of Minneapolis in January by opening the windows of a house.
They did their computer models and such with the nukes on a hurricane. No effect in most cases. Strengthened it in others. (Created more heat and low pressure.)
At least that is what I read awhile back.
A hurricane is relatively thin. This one is probably 500 miles or more in diameter, but it is less than 10 miles thick. Most of it is in the first 5 miles of the atmosphere. It is shaped roughly like a CD.
In the 50's the Navy tried to destroy icebergs by bombing them..failed miserably..
If you're going to nuke a hurricane, I would save it for a war with China. If it works (dissipates the storm), hey, good for them and hopefully good for combat operations. But a cyclonic storm is a heat engine, and you would be giving it a whole lot of energy, and the mushroom cloud comes from surface elements being swept into the pressure low. You could make it a more powerful storm, even if only for a short while. So, try it in someone else's back yard first.