Personally, I think it's almost inconceivable that we could be alone in such a vast universe! But as I say, the thing that interests me almost as much is, how prevalent is life? Is the galaxy teeming with it? Or will we only find it in one in a million galaxies?
SETI does not even aspire to provide any measure of the prevalence of life, but rather of civilizations.
PS. If we are to 'find' life in but one in a million galaxies then we've probably already found all the life that humanity is actually ever gonna find.. ;^)