Good grief, js1138, how tendentious can you get???!!! With or without instruments precisely calibrated for our purposes or otherwise, observation is necessarily still observation. It's nice to have nifty, high-tech instruments that allow us to extend our "vision." At the end of the day, I think probably mathematics helps us do the same thing.
But the point is, in the final analysis, it all boils down to this: HUMAN OBSERVATION. No more, no less.
FWIW. Thank you so much for writing, js....
What makes science different is the iterative process of observation, analysis, speculation and testing. Observation by itself is never enough.