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Again due to the size of the universe, which you and others, including myself, don't even understand, even the most intelligent life in the universe might have no means of leaving their planet.
Please. If the most intelligent life in the universe can't get off their planet, then they ain't very smart are they? And the size of the universe (understandable by you or not) is irrelevant.

Please. If the most intelligent life in the universe can't get off their planet, then they ain't very smart are they?

What if their planet lacks the resources to even build a suitable spacecraft? What if their life spans are only 5 years? What if they are biologically unfit for space travel?

And the size of the universe is irrelevant.

Irrelevant? Really?

It would seem to me that great distances would present the largest problems to any life forms.

If the distances of the vastness of the universe are irrelevant, what are the big obstacles for interstellar travel throughout the universe? And why haven't we had manned missions to Mars and bases on the lunar surface?

And the size of the universe (understandable by you or not) is irrelevant.

Also, you just implied that you know the size of the universe, since the observable universe is only a part of the physical universe, what is the size?