"What is best in life?" To crush the jihadists, to drive their collaborators before you, and to hear the lamentations of their mullahs! Allahu fubar!
I'm not afraid to bring the hammer down -- I just want to hit the right nail.
And (if you have one), I'd like to hear reasons other than the claim that the destruction of Mecca would end islam. I've already discussed that one once, and have no desire to do so again. But I am curious as to the other "practical" reasons to make Mecca the preferred target over the capitals.