One can always put a nuclear tip on a missile and explode it close to an oncoming missile. That is being than 500,000 people in Los Angeles, San Francisco, Seattle or Portland getting nuked.
Trying to defend it better than getting nuked... But I guess the liberals just want to bend over and kiss their rear end goodbye if Red China, North Korea, or Iran launch nuclear missiles.
Even if it is not close enough to incinerate a warhead with a nuke, a high altitude air burst's EMP could render the warhead harmless (other than being a fast falling projectile..)
There has been considerable analysis of this method. It is not as effective as kinetic weapons due to fratricide.