Not really. The court will shift some; but not dramatically. O'Conner is not predictably wrong on constitutional issues. Just not predictably right. The big shift will come if and when Stevens, Kennedy, or Ginsburg retire. They are consistently wrong on the big issues and they are either old or have had serious health problems. That's the left's nightmare.
Another interesting battle heating up....Between Kennedy's far left and McCain's Gang 0f 14. McCain was just on FOX and said there won't be a filibuster. He said, "the president will nominate a conservative, and will get an up or down vote". Sounded like a guarantee to me. And this was after the FOX anchor told him about Kennedy's inflammatory statement, almost a carbon copy of what some of the extreme far left fringe is saying about conservative picks.