Heinlein seemed to think it would be challenging to start over occasionally.
If one felt perpetually youthful, why not?
Still ... compound interest...
There was a book of stories on the subject of immortality. How would you deal with it? Everything, even Heinlein, would get kind of plebian. You could probably master every musical instrument, all the math there is, run every white water creek and climb every face of every mountain and you would still be faced with immortality. I suppose you could get a 40 acre farm and tend it with scissors to keep busy.