I don't think it's major in a technological sense. In a previous life a couple of decades ago I worked on some prototype reprocessing lines that not only partitioned the "waste" (which it really isn't, since it is very useful material), but also allowed implementation of the preliminary steps for full actinide recycle, which you almost have to do to keep volumes reasonably manageable in the long term.
We need only the will to do it and the political courage to move forward on licensing facilities. In addition to LWR material reprocessing, check out the IFR concept. A closed fuel cycle. Very sweet indeed...
Unfortunately, political courage is in short supply. I did, however, find it profoundly interesting that BOTH presidential candidates embraced nuclear power (of course, the one that lost would have been incapable of promoting it because of all his IOUs to the non-nuke crowd).